ACVR1C/ALK7 anticorps (N-Term)

N° du produit ABIN6990976

Détail du produit anti-ACVR1C/ALK7 anticorps

Antigène: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Épitope: AA 130-180, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACVR1C/ALK7 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.

Purification: ACVR1C Antibody is affinity chromatography purified via peptide column.

Immunogène: ACVR1C antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ACVR1C. The immunogen is located within amino acids 130 - 180 of ACVR1C.

Isotype: IgG

Information d'application

Indications d'application: ACVR1C antibody can be used for detection of ACVR1C by Western blot at 1 and 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ACVR1C Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ACVR1C antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ACVR1C/ALK7

Antigène: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Autre désignation: ACVR1C (ACVR1C Produits)

Synonymes: anticorps ACVRLK7, anticorps ALK7, anticorps Alk-7, anticorps C230097P10, anticorps Alk7, anticorps habrec1, anticorps activin A receptor type 1C, anticorps activin A receptor, type IC, anticorps ACVR1C, anticorps Acvr1c

Sujet: ACVR1C Antibody: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.

ID gène: 90

UniProt: Q04771, Q8NER5

Pathways: Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity