ZC3H12A anticorps (AA 330-380)

N° du produit ABIN6991306

Détail du produit anti-ZC3H12A anticorps

Antigène: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Épitope: AA 330-380

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZC3H12A est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: This ZC3H12A antibody is predicted to have no cross-reactivity to other members of the ZC3H12 protein family.

Purification: ZC3H12A Antibody is affinity chromatography purified via peptide column.

Immunogène: ZC3H12A antibody was raised against a 17 amino acid synthetic peptide near the center of human ZC3H12A. The immunogen is located within amino acids 330 - 380 of ZC3H12A.

Isotype: IgG

Information d'application

Indications d'application: ZC3H12A antibody can be used for detection of ZC3H12A by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZC3H12A Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ZC3H12A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ZC3H12A

Antigène: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Autre désignation: ZC3H12A (ZC3H12A Produits)

Synonymes: anticorps CGA, anticorps MCPIP, anticorps MCPIP1, anticorps RP3-423B22.1, anticorps dJ423B22.1, anticorps BC036563, anticorps Mcpip1, anticorps RGD1306776, anticorps chromogranin A, anticorps zinc finger CCCH-type containing 12A, anticorps zinc finger CCCH type containing 12A, anticorps CHGA, anticorps ZC3H12A, anticorps Zc3h12a

Sujet: ZC3H12A Antibody: ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPgamma, demonstrating the complex roles ZC3H12A plays.

Poids moléculaire: Predicted: 66 kDa

Observed: 6 kDa

ID gène: 80149

NCBI Accession: NP_079355

UniProt: Q5D1E8

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation