SPINK7/ECRG2 anticorps (C-Term)

N° du produit ABIN6991593

Détail du produit anti-SPINK7/ECRG2 anticorps

Antigène: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp SPINK7/ECRG2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: ECRG2 antibody is predicted to not cross-react with other ECRG family members

Purification: ECRG2 Antibody is affinity chromatography purified via peptide column.

Immunogène: ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. The immunogen is located within the last 50 amino acids of ECRG2.

Isotype: IgY

Information d'application

Indications d'application: ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ECRG2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SPINK7/ECRG2

Antigène: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Autre désignation: ECRG2 (SPINK7 Produits)

Synonymes: anticorps Ecg2, anticorps Ecrg2, anticorps OM, anticorps ECG2, anticorps ECRG2, anticorps EG408198, anticorps serine peptidase inhibitor, Kazal type 7, anticorps serine peptidase inhibitor, Kazal type 7 (putative), anticorps Spink7, anticorps SPIK7, anticorps SPINK7

Sujet: ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

Poids moléculaire: Predicted: 9 kDa

Observed: 14 kDa

ID gène: 84651

UniProt: P58062