WNT5B anticorps (AA 130-180)

N° du produit ABIN6992093

Détail du produit anti-WNT5B anticorps

Antigène: WNT5B (Wingless-Type MMTV Integration Site Family, Member 5B (WNT5B))

Épitope: AA 130-180

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNT5B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: WNT5 antibody is human, mouse and rat reactive. WNT5 antibody will detect both WNT5A and WNT5B. At least two isoforms of WNT5B are known to exist, this antibody will detect both isoforms.

Purification: WNT5 antibody is affinity chromatography purified via peptide column.

Immunogène: WNT5 antibody was raised against a 15 amino acid peptide near the center of human WNT5B. The immunogen is located within amino acids 130 - 180 of WNT5.

Isotype: IgG

Information d'application

Indications d'application: WNT5 antibody can be used for detection of WNT5 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: WNT5 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: WNT5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur WNT5B

Antigène: WNT5B (Wingless-Type MMTV Integration Site Family, Member 5B (WNT5B))

Autre désignation: WNT5 (WNT5B Produits)

Synonymes: anticorps wnt-5b, anticorps xwnt5b, anticorps WNT5B, anticorps AW545702, anticorps Wnt-5b, anticorps xwnt-5c, anticorps CHUNP6928, anticorps id:ibd5111, anticorps ppt, anticorps wnt-5, anticorps wnt5, anticorps wnt[b], anticorps wu:fk85g06, anticorps Wnt family member 5B, anticorps wingless-type MMTV integration site family, member 5B, anticorps Wnt family member 5B S homeolog, anticorps wingless-type MMTV integration site family, member 5b, anticorps wnt5b, anticorps WNT5B, anticorps Wnt5b, anticorps wnt5b.S

Sujet: WNT5A and WNT5B are near-identical members of the WNT gene family, which consists of structurally related genes which encode secreted signaling proteins that have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis (1,2). WNT5A and WNT5B coordinate chondrocyte proliferation and differentiation by differentially regulating cyclin D1 and p130 expression, as well as chondrocyte-specific Col2a1 expression (3). Up-regulation of WNT5A and WNT5B has been observed in several types of human cancers, suggesting that they may be useful as diagnostic markers or potent therapeutic targets (4).

Poids moléculaire: Predicted: 39 kDa

Observed: 465 kDa

ID gène: 81029

NCBI Accession: NP_110402

UniProt: Q9H1J7

Pathways: Signalisation WNT, Embryonic Body Morphogenesis, Positive Regulation of fat Cell Differentiation