SLCO1B1 anticorps (C-Term)

N° du produit ABIN6992143

Détail du produit anti-SLCO1B1 anticorps

Antigène: SLCO1B1 (Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLCO1B1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins.

Purification: SLCO1B1 antibody is affinity chromatography purified via peptide column.

Immunogène: SLCO1B1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLCO1B1. The immunogen is located within the last 50 amino acids of SLCO1B1.

Isotype: IgG

Information d'application

Indications d'application: SLCO1B1 antibody can be used for detection of SLCO1B1 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SLCO1B1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SLCO1B1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur SLCO1B1

Antigène: SLCO1B1 (Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1))

Autre désignation: SLCO1B1 (SLCO1B1 Produits)

Synonymes: anticorps HBLRR, anticorps LST-1, anticorps LST1, anticorps OATP-C, anticorps OATP1B1, anticorps OATP2, anticorps OATPC, anticorps SLC21A6, anticorps SLCO1B1, anticorps solute carrier organic anion transporter family member 1B1, anticorps SLCO1B1, anticorps LOC100011628, anticorps LOC100448597

Sujet: SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2). It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3). SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4).

Poids moléculaire: Predicted: 76 kDa

Observed: 75 kDa

ID gène: 10599

NCBI Accession: NP_006437

UniProt: Q9Y6L6