NFkB anticorps (AA 805-892)

N° du produit ABIN7442525

Cet anticorps anti-NFkB est un anticorps Lapin Polyclonal détectant NFkB dans WB, IHC, IP et ICC. Adapté pour Humain.

Aperçu rapide pour NFkB anticorps (AA 805-892) (ABIN7442525)

Highlights:

• High quality NFkB Anticorps primaire for the detection of NFkB.
• Reliable product with high standard validation data

Antigène: NFkB (Nuclear Factor kappa B (NFkB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFkB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Détail du produit anti-NFkB anticorps

Épitope: AA 805-892

Fonction: Polyclonal Antibody to Nuclear Factor Kappa B (NFkB)

Specificité: The antibody is a rabbit polyclonal antibody raised against NFkB. It has been selected for its ability to recognize NFkB in immunohistochemical staining and western blotting.

Réactivité croisée: Souris, Rat

Purification: Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Immunogène: Recombinant Nuclear Factor Kappa B (NFkB) corresdonding to Gln805~Ser892 (Accession # P19838) with N-terminal His and GST Tag

Isotype: IgG

Informations sur le produit:

What can the NFkB Antibody ABIN7442525 be used for?: This polyclonal NFkB Antibody detects NFkB. The NFkB Antibody has been validated for various applications and can be used for the detection of NFkB and derivatives by Western Blotting, Immunohistochemistry, Immunoprecipitation, Immunocytochemistry.

What validation data is available for this NFkB Antibody?: The Anticorps primaire has currently 6 product images that show its performance in a variety of applications. The product is currently available in 1 mL, 20 μL, 100 μL, 200 μL quantities. NFkB Antibody for the detection of NFkB and derivatives.

What is the function of NFkB?: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Information d'application

Indications d'application: Western blotting: 0.5-2 μg/mL,Immunohistochemistry: 5-20 μg/mL,Immunocytochemistry: 5-20 μg/mL,Optimal working dilutions must be determined by end user.

Commentaires:

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.01M PBS, pH 7.4, containing 0.05 % Proclin-300, 50 % glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Date de péremption: 24 months

Détails sur NFkB

Antigène: NFkB (Nuclear Factor kappa B (NFkB))

Autre désignation: NFkB

Sujet: NF-KB1, EBP-1, KBF1, NF-Kappa-B, NFKB-P105, NFKB-P50, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1, Nuclear factor NF-kappa-B p105 subunit

UniProt: P19838

Pathways: Ubiquitin Proteasome Pathway, S100 Proteins