anticorps HDBP-2, anticorps HDBP2, anticorps HDRF-2, anticorps PBF, anticorps PRF-1, anticorps PRF1, anticorps Si-1-8-14, anticorps sb:cb866, anticorps zgc:55309, anticorps si:ch211-89p3.1, anticorps si:ch211-223o11.1, anticorps ZNF395, anticorps pbf, anticorps prf1, anticorps hdbp2, anticorps prf-1, anticorps si-1-8-14, anticorps BC053701, anticorps Gm910, anticorps si:ch211-63o20.5, anticorps wu:fa14e01, anticorps zgc:158367, anticorps zinc finger protein 395, anticorps zinc finger protein 395 S homeolog, anticorps family with sequence similarity 49, member A, anticorps zinc finger protein 395b, anticorps zinc finger protein 395a, anticorps ZNF395, anticorps znf395.S, anticorps fam49a, anticorps znf395, anticorps Zfp395, anticorps Znf395, anticorps znf395b, anticorps znf395a
Sujet
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3'-CCGG-5' sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm.