Ki-67 anticorps

N° du produit ABIN7250094

Détail du produit anti-Ki-67 anticorps

Antigène: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ki-67 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Attributs du produit: Monoclonal Antibody

Purification: Protein A purification

Immunogène: Synthetic Peptide

Clone: 8K5

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100-1:300, IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Ki-67

Antigène: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Autre désignation: KI67 (MKI67 Produits)

Synonymes: anticorps MKI67, anticorps kia, anticorps mki67, anticorps MGC132156, anticorps D630048A14Rik, anticorps Ki-67, anticorps Ki67, anticorps KIA, anticorps MIB-1, anticorps marker of proliferation Ki-67, anticorps marker of proliferation Ki-67 L homeolog, anticorps marker of proliferation Ki-67 S homeolog, anticorps antigen identified by monoclonal antibody Ki 67, anticorps antigen identified by monoclonal antibody Ki-67, anticorps nucleolar protein interacting with the FHA domain of MKI67, anticorps MKI67, anticorps mki67, anticorps mki67.L, anticorps mki67.S, anticorps Mki67, anticorps NIFK

Sujet: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process