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EFCAB4B anticorps

EFCAB4B Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7257401
  • Antigène Voir toutes EFCAB4B Anticorps
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Reactivité
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    • 2
    Lapin
    Clonalité
    • 23
    Polyclonal
    Conjugué
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp EFCAB4B est non-conjugé
    Application
    • 23
    • 13
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein of human CRACR2A (NP_001138430.1).
    Isotype
    IgG
    Top Product
    Discover our top product EFCAB4B Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Autre désignation
    CRACR2A (EFCAB4B Produits)
    Synonymes
    anticorps CRACR2A, anticorps Gm1073, anticorps Gm462, anticorps calcium release activated channel regulator 2A, anticorps CRACR2A, anticorps Cracr2a
    Sujet
    Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
    Poids moléculaire

    Observed_MW: 45 kDa

    Calculated_MW: 45 kDa/83 kDa

    ID gène
    84766
    UniProt
    Q9BSW2
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