Macrophage Scavenger Receptor 1 anticorps

N° du produit ABIN7257701

Détail du produit anti-Macrophage Scavenger Receptor 1 anticorps

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human MSR1 (NP_619729.1).

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Macrophage Scavenger Receptor 1

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Autre désignation: MSR1 (MSR1 Produits)

Synonymes: anticorps CD204, anticorps SCARA1, anticorps SR-A, anticorps SRA, anticorps phSR1, anticorps phSR2, anticorps MRS-A, anticorps MSR, anticorps MSR-A, anticorps SR-AI, anticorps SR-AII, anticorps Scara1, anticorps Scvr, anticorps MSR1, anticorps RGD1564316, anticorps macrophage scavenger receptor 1, anticorps scavenger receptor class A member 5, anticorps MSR1, anticorps Msr1, anticorps SCARA5

Sujet: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

ID gène: 4481

UniProt: P21757