TSPO anticorps (AA 31-130)

N° du produit ABIN702475

Détail du produit anti-TSPO anticorps

Antigène: TSPO (Peripheral-Type Benzodiazepine Receptor (TSPO))

Épitope: AA 31-130

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSPO est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Peripheral type Benzodiazepine Receptor

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur TSPO

Antigène: TSPO (Peripheral-Type Benzodiazepine Receptor (TSPO))

Autre désignation: PBR (TSPO Produits)

Synonymes: anticorps LOC732875, anticorps LOC100136652, anticorps LOC100280949, anticorps BZRP, anticorps TSPO, anticorps Bzrp, anticorps IBP, anticorps PBR, anticorps Tspo1, anticorps MBR, anticorps PTBZR02, anticorps Ptbzr, anticorps RATPTBZR02, anticorps BPBS, anticorps DBI, anticorps PBS, anticorps PKBS, anticorps PTBR, anticorps mDRC, anticorps pk18, anticorps peripheral-type benzodiazepine receptor, anticorps Peripheral-type benzodiazepine receptor, anticorps putative peripheral-type benzodiazepine receptor, anticorps translocator protein, anticorps translocator protein homolog, anticorps hypothetical protein, anticorps LOC732875, anticorps MAV_3896, anticorps xccb100_2086, anticorps Smp_102510, anticorps Sros_1911, anticorps tspo, anticorps LOC100280949, anticorps PGTG_16395, anticorps TSPO, anticorps Tspo

Sujet:

Synonyms: BPBS, BZRP, DBI, IBP, Isoquinoline carboxamide-binding protein, MBR, mDRC, Mitochondrial benzodiazepine receptor, PBR, PBS, Peripheral benzodiazepine receptor, Peripheral benzodiazepine receptor-related protein, Peripheral type benzodiazepine receptor, pk18, PKBS, PTBR, Ptbzr, PTBZR02, RATPTBZR02, translocator protein 18 kDa, Translocator protein, TSPO, Tspo1, Benzodiazapine receptor peripheral, Benzodiazepine peripheral binding site.

Background: PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.

ID gène: 1622

Pathways: Cellular Response to Molecule of Bacterial Origin