Presenilin 2 anticorps (Intracellular)

N° du produit ABIN7043554

Cet anticorps Lapin Polyclonal détecte spécifiquement Presenilin 2 dans WB et IHC. Il présente une réactivité envers Rat.

Aperçu rapide pour Presenilin 2 anticorps (Intracellular) (ABIN7043554)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Presenilin 2 anticorps

Épitope: AA 33-48, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Presenilin-2

Specificité: Intracellular, N-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - 13,14 amino acid residues identical

Attributs du produit: Anti-Presenilin-2 Antibody (ABIN7043554, ABIN7044526 and ABIN7044527) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize PSEN2 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)DSRPGPEDGENTAQWR, corresponding to amino acid residues 33-48 of rat Presenilin-2

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200-1:400

Commentaires:

Negative Control: (ABIN7236597)

Blocking Peptide: (ABIN7236597)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: PSEN2

Sujet: Psen2, Ps2, Psnl2, AD3LP, AD5, E5-1 STM-2,Presenilin 2 (PS2) is the catalytic subunit of a tetrameric complex containing presenilin-1 or 2, anterior pharynx defective 1 (APH1), nicastrin, and PEN-21.The presenilin complex is the founding member of a unique class of GXGD aspartyl proteases that catalyze the cleavage of the transmembrane domains of Type I membrane proteins including amyloid precursor protein (APP) and Notch1. Other members of this protease family include signal peptide peptidases (SPP) and a variety of archaeal homologs2.PS1 and PS2 proteins have nine helical TM domains arranged with the hydrophilic, flexible N terminus in the cytosol and the C terminus protruding into the lumen or extracellular space3.PS2 shares similarity with PS 1 and the crucial difference between them appears to be a "[DIE]xxxL/I/M" motif present only in PS2 which interacts in a phosphorylation dependent manner with AP-1 complexes and targets PS2 to the late endosome/lysosome complex. The absence of this sequence motif in PS1 allows for the wider subcellular location of PS1 in cell membranes4.Presenilin mutations have been shown to be correlated with occurrence of familial Alzheimer's disease5.

Alternative names: Psen2, Ps2, Psnl2, AD3LP, AD5, E5-1 STM-2

ID gène: 81751

NCBI Accession: NM_000447

UniProt: O88777

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway