Presenilin 2 anticorps (Intracellular, N-Term)

N° du produit ABIN7043554

Cet anticorps Lapin Polyclonal détecte spécifiquement Presenilin 2 dans WB et IHC. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour Presenilin 2 anticorps (Intracellular, N-Term) (ABIN7043554)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Presenilin 2 anticorps

Épitope: AA 33-48, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Presenilin-2

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - 13,14 amino acid residues identical

Attributs du produit: Anti-Presenilin-2 Antibody (ABIN7043554, ABIN7044526 and ABIN7044527) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize PSEN2 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DSRPGPEDGENTAQWR, corresponding to amino acid residues 33-48 of rat Presenilin-2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236597)

Blocking Peptide: (ABIN7236597)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: PSEN2

Sujet:

Synonyms: Psen2, Ps2, Psnl2, AD3LP, AD5, E5-1 STM-2

Description: Presenilin 2 (PS2) is the catalytic subunit of a tetrameric complex containing presenilin-1 or 2, anterior pharynx defective 1 (APH1), nicastrin, and PEN-21.The presenilin complex is the founding member of a unique class of GXGD aspartyl proteases that catalyze the cleavage of the transmembrane domains of Type I membrane proteins including amyloid precursor protein (APP) and Notch1. Other members of this protease family include signal peptide peptidases (SPP) and a variety of archaeal homologs2.PS1 and PS2 proteins have nine helical TM domains arranged with the hydrophilic, flexible N terminus in the cytosol and the C terminus protruding into the lumen or extracellular space3.PS2 shares similarity with PS 1 and the crucial difference between them appears to be a "[DIE]xxxL/I/M" motif present only in PS2 which interacts in a phosphorylation dependent manner with AP-1 complexes and targets PS2 to the late endosome/lysosome complex. The absence of this sequence motif in PS1 allows for the wider subcellular location of PS1 in cell membranes4.Presenilin mutations have been shown to be correlated with occurrence of familial Alzheimer's disease5.

ID gène: 81751

NCBI Accession: NM_000447

UniProt: O88777

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway