MIIP anticorps

N° du produit ABIN7074626

Détail du produit anti-MIIP anticorps

Antigène: MIIP (Migration and Invasion Inhibitory Protein (MIIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIIP est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse MIIP

Information d'application

Indications d'application: IHC/IF (H) 1:600-1:1200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur MIIP

Antigène: MIIP (Migration and Invasion Inhibitory Protein (MIIP))

Autre désignation: MIIP (MIIP Produits)

Synonymes: anticorps IIP45, anticorps AA553001, anticorps AI853621, anticorps D4Wsu114e, anticorps Iip45, anticorps migration and invasion inhibitory protein, anticorps MIIP, anticorps Miip

Sujet: MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression.

ID gène: 28010

NCBI Accession: NP_001020536

UniProt: A2A7Y5