PKD1 anticorps
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- Antigène Voir toutes PKD1 Anticorps
- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PKD1 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée
- Humain
- Purification
- Affinity purification
- Immunogène
- Recombinant protein corresponding to Mouse Polycystin 1
- Top Product
- Discover our top product PKD1 Anticorps primaire
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- Indications d'application
- WB (H) 1: 500-1: 1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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- Antigène
- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
- Autre désignation
- Polycystin 1 (PKD1 Produits)
- Synonymes
- anticorps PBP, anticorps Pc-1, anticorps TRPP1, anticorps PC1, anticorps mFLJ00285, anticorps polycystin 1, transient receptor potential channel interacting, anticorps polycystin 1, transient receptor poteintial channel interacting, anticorps polycystin-1, anticorps PKD1, anticorps Pkd1, anticorps LOC749291
- Sujet
- This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.
- Poids moléculaire
- >460 kDa
- ID gène
- 18763
- NCBI Accession
- NP_038658
- UniProt
- O08852
- Pathways
- Myometrial Relaxation and Contraction, Maintenance of Protein Location
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