The clone 4F5, a mouse monoclonal antibody recognizes anti- FcγRIIb, a cell surface protein also known as CD32b. FcγRII has two major isoforms named FcγRIIa and FcγRIIb with high degree of homology. The clone 4F5 selectively reacts with FcγRIIb but not with FcγRIIa. The CD32b antigen is widely expressed on the cell surface of circulating B lymphocytes, monocytes, neutrophils, myeloid dendritic cells (DCs), platelets and at very low levels on plasmacytoid DCs. FcγRs (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2) play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. Published reports claimed that 4F5 partially blocks the ligand-binding of FcRIIb and mediates an inhibitory signal by co-cross-linking FcRIIb with activating FcRs. Clone 4F5 supports study of the expression, regulation, and function of FcγRIIb and may be useful in the area of therapeutic applications where the modulation of FcγRIIb is required.
Purification
Purified
Pureté
>95 %
Classe de qualité
GMP Grade
Immunogène
Recombinant human FcgammaRIIb/c (CD32b) extracellular domain
anticorps CD32, anticorps CD32B, anticorps FCG2, anticorps FCGR2, anticorps IGFR2, anticorps FCGR2B, anticorps AI528646, anticorps F630109E10Rik, anticorps Fc[g]RII, anticorps FcgRII, anticorps Fcgr2, anticorps Fcgr2a, anticorps Fcr-2, anticorps Fcr-3, anticorps Ly-17, anticorps Ly-m20, anticorps LyM-1, anticorps Lym-1, anticorps FCRII, anticorps FcRII, anticorps Fc fragment of IgG receptor IIb, anticorps Fc fragment of IgG, low affinity IIb, receptor (CD32), anticorps Fc receptor, IgG, low affinity IIb, anticorps low affinity immunoglobulin gamma Fc region receptor II, anticorps FCGR2B, anticorps Fcgr2b, anticorps LOC100856270
Sujet
The clone 4F5, a mouse monoclonal antibody recognizes anti- FcγRIIb, a cell surface protein also known as CD32b. FcγRII has two major isoforms named FcγRIIa and FcγRIIb with high degree of homology. The clone 4F5 selectively reacts with FcγRIIb but not with FcγRIIa. The CD32b antigen is widely expressed on the cell surface of circulating B lymphocytes, monocytes, neutrophils, myeloid dendritic cells (DCs), platelets and at very low levels on plasmacytoid DCs. FcγRs (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2) play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. Published reports claimed that 4F5 partially blocks the ligand-binding of FcRIIb and mediates an inhibitory signal by co-cross-linking FcRIIb with activating FcRs. Clone 4F5 supports study of the expression, regulation, and function of FcγRIIb and may be useful in the area of therapeutic applications where the modulation of FcγRIIb is required.