HACE1 anticorps

N° du produit ABIN7091196

Détail du produit anti-HACE1 anticorps

Antigène: HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HACE1 est non-conjugé

Application: Western Blotting (WB)

Homologie: Human

Immunogène: Recombinant human HACE1.

Clone: B4F6

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur HACE1

Antigène: HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))

Autre désignation: HACE1 (HACE1 Produits)

Synonymes: anticorps HACE1, anticorps 1700042J16Rik, anticorps A730034A22Rik, anticorps BC025474, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog, anticorps HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1, anticorps HACE1, anticorps hace1, anticorps hace1.L, anticorps Hace1

Sujet:

Synonyms: E3 ubiquitin-protein ligase HACE1, HACE 1, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, KIAA1320, HACE1_HUMAN.

Background: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

ID gène: 57531

UniProt: Q8IYU2