CRBN anticorps
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- Antigène Voir toutes CRBN Anticorps
- CRBN (Cereblon (CRBN))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CRBN est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Purification
- Immunogen affinity purified
- Pureté
- ≥95 % as determined by SDS-PAGE
- Immunogène
- cereblon
- Isotype
- IgG
- Top Product
- Discover our top product CRBN Anticorps primaire
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- Indications d'application
- WB: 1:500-1:2000, IHC: 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Date de péremption
- 12 months
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- Antigène
- CRBN (Cereblon (CRBN))
- Autre désignation
- CRBN (CRBN Produits)
- Synonymes
- anticorps zgc:92404, anticorps mrt2a, anticorps F3N11.21, anticorps MRT2, anticorps MRT2A, anticorps 2610203G15Rik, anticorps 2900045O07Rik, anticorps AF229032, anticorps AW108261, anticorps piL, anticorps cereblon, anticorps ATP-dependent protease La (LON) domain protein, anticorps crbn, anticorps CRBN, anticorps AT2G25740, anticorps Crbn
- Sujet
- Synonyms:cereblon, CRBN, MRT2A, Protein cereblon Background:Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
- Poids moléculaire
- 53 kDa
- ID gène
- 51185
- UniProt
- Q96SW2
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