LATS1 anticorps

N° du produit ABIN7115777

Détail du produit anti-LATS1 anticorps

Antigène: LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LATS1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: LATS, large tumor suppressor, homolog 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur LATS1

Antigène: LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Autre désignation: LATS1 (LATS1 Produits)

Synonymes: anticorps WARTS, anticorps wts, anticorps AW208599, anticorps Lats, anticorps si:dkey-181i3.5, anticorps wu:fc19a11, anticorps zgc:123219, anticorps lats1, anticorps RGD1564085, anticorps warts, anticorps large tumor suppressor kinase 1, anticorps large tumor suppressor, anticorps large tumor suppressor kinase 1 S homeolog, anticorps LATS1, anticorps Lats1, anticorps lats1, anticorps lats1.S

Sujet: Synonyms:LATS1, WARTS, WARTS protein kinase, wts Background:Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

Poids moléculaire: 140 kDa

ID gène: 9113

UniProt: O95835

Pathways: Regulation of Actin Filament Polymerization, Maintenance of Protein Location