MAGOH anticorps

N° du produit ABIN7116004

Détail du produit anti-MAGOH anticorps

Antigène: MAGOH (Mago-Nashi Homolog (MAGOH))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAGOH est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: mago-nashi homolog, proliferation-associated(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur MAGOH

Antigène: MAGOH (Mago-Nashi Homolog (MAGOH))

Autre désignation: MAGOH (MAGOH Produits)

Synonymes: anticorps MAGOH1, anticorps MAGOHA, anticorps Mago-m, anticorps Mos2, anticorps MAGOH, anticorps zgc:112220, anticorps mago, anticorps xl-mago, anticorps CG9401, anticorps Dm MGN, anticorps DmMago, anticorps Dmel\CG9401, anticorps MGN, anticorps Mago, anticorps Magoh, anticorps l(2)57Ca, anticorps mgn, anticorps magoh, anticorps mago homolog, exon junction complex core component, anticorps protein mago nashi homolog, anticorps mago homolog, exon junction complex core component L homeolog, anticorps mago nashi, anticorps MAGOH, anticorps Magoh, anticorps LOC736868, anticorps magoh, anticorps magoh.L, anticorps mago, anticorps LOC106584057

Sujet: Synonyms:MAGOHA Background:Core component of the splicing-dependent multiprotein exon junction complex(EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay(NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.

Poids moléculaire: 17 kDa

ID gène: 4116

UniProt: P61326