MAP4K6 anticorps

N° du produit ABIN7116324

Détail du produit anti-MAP4K6 anticorps

Antigène: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP4K6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: misshapen-like kinase 1(zebrafish)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur MAP4K6

Antigène: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Autre désignation: MINK1 (MINK1 Produits)

Synonymes: anticorps MINK1, anticorps MINK, anticorps B55, anticorps MAP4K6, anticorps YSK2, anticorps ZC3, anticorps hMINK, anticorps hMINKbeta, anticorps MEKKK 6, anticorps Map4k6, anticorps RP23-122P1.6, anticorps Ysk2, anticorps misshapen like kinase 1, anticorps misshapen-like kinase 1, anticorps misshapen-like kinase 1 (zebrafish), anticorps MINK1, anticorps Mink1

Sujet: Synonyms:B55, MAP4K6, Background:Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Poids moléculaire: 150 kDa

ID gène: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane