NR5A1 anticorps

N° du produit ABIN7117011

Détail du produit anti-NR5A1 anticorps

Antigène: NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR5A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: nuclear receptor subfamily 5, group A, member 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur NR5A1

Antigène: NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))

Autre désignation: NR5A1 (NR5A1 Produits)

Synonymes: anticorps AD4BP, anticorps ELP, anticorps FTZ1, anticorps FTZF1, anticorps POF7, anticorps SF-1, anticorps SF1, anticorps SPGF8, anticorps SRXY3, anticorps Ad4BP, anticorps ELP-3, anticorps Ftz-F1, anticorps Ftzf1, anticorps Ad4BP/SF-1, anticorps Ad4bp, anticorps Sf-1, anticorps NR5A1, anticorps sf-1, anticorps elp, anticorps sf1, anticorps ftz1, anticorps ad4bp, anticorps ftzf1, anticorps SF-1/Ad4BP, anticorps SI:zC167P9.2, anticorps ff1d, anticorps nr5a2l, anticorps nuclear receptor subfamily 5 group A member 1, anticorps nuclear receptor subfamily 5, group A, member 1, anticorps nuclear receptor subfamily 5 group A member 1 L homeolog, anticorps nuclear receptor subfamily 6 group A member 1, anticorps nuclear receptor subfamily 5, group A, member 1b, anticorps NR5A1, anticorps Nr5a1, anticorps nr5a1.L, anticorps nr5a1, anticorps NR6A1, anticorps nr5a1b

Sujet: Synonyms:AD4BP, FTZF1, SF1 Background:Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine(By similarity). Binds phospholipids with a phosphatidylinositol(PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Poids moléculaire: 53 kDa

ID gène: 2516

UniProt: Q13285

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Maintenance of Protein Location