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MMP2 anticorps (AA 401-500)

MMP2 Reactivité: Humain, Rat, Souris, Lapin WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN707426
  • Antigène Voir toutes MMP2 Anticorps
    MMP2 (Matrix Metalloproteinase 2 (MMP2))
    Épitope
    • 16
    • 16
    • 15
    • 11
    • 10
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivité
    • 151
    • 79
    • 64
    • 48
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Rat, Souris, Lapin
    Hôte
    • 124
    • 42
    • 1
    Lapin
    Clonalité
    • 121
    • 46
    Polyclonal
    Conjugué
    • 80
    • 14
    • 13
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MMP2 est non-conjugé
    Application
    • 135
    • 58
    • 51
    • 38
    • 38
    • 37
    • 30
    • 29
    • 17
    • 15
    • 14
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Lapin, Rat
    Homologie
    Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MMP-2
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Bi, Zhang, Du, Zhang, Deng, Liu, Zhang: "Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice." dans: Scientific reports, Vol. 7, Issue 1, pp. 10001, (2019) (PubMed).

    Gasparski, Ozarkar, Beningo: "Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro." dans: Journal of cell science, Vol. 130, Issue 11, pp. 1965-1978, (2018) (PubMed).

    Wang, Nikhil, Viccaro, Chang, White, Shah: "Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer." dans: BMC biology, Vol. 15, Issue 1, pp. 10, (2017) (PubMed).

    Wang, Nikhil, Viccaro, Chang, Jacobsen, Sandusky, Shah: "The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma." dans: Journal of cell science, Vol. 130, Issue 6, pp. 1078-1093, (2017) (PubMed).

    Liu, Chi, Lu, Zhang, Yamakawa: "Reversion-inducing-cysteine-rich Protein with Kazal Motif Is Involved in Intimal Hyperplasia in Carotid Arteries: A New Insight in the Prevention of Restenosis after Vascular Angioplasty." dans: Annals of vascular surgery, Vol. 29, Issue 6, pp. 1293-9, (2015) (PubMed).

    Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: "The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model." dans: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 4, pp. 304-14, (2014) (PubMed).

    Fan, Han, Zhu, Zhang, Zhu: "Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates." dans: Analytical chemistry, Vol. 86, Issue 24, pp. 12398-405, (2014) (PubMed).

  • Antigène
    MMP2 (Matrix Metalloproteinase 2 (MMP2))
    Autre désignation
    MMP-2 (MMP2 Produits)
    Synonymes
    anticorps 2-MMP, anticorps CG1794, anticorps DM2-MMP, anticorps Dm2-MMP, anticorps Dmel\\CG1794, anticorps MMP2, anticorps anon-WO0118547.84, anticorps dm-2MMP, anticorps dmmp2, anticorps l(2)02353, anticorps mmp2, anticorps wu:fa99h12, anticorps wu:fk89d01, anticorps fgmmp-2, anticorps Mmp-2, anticorps LOC100135793, anticorps Clg4a, anticorps GelA, anticorps MMP-2, anticorps CLG4, anticorps CLG4A, anticorps MMP-II, anticorps MONA, anticorps TBE-1, anticorps matrix metallopeptidase 2, anticorps Matrix metalloproteinase 2, anticorps matrix metalloproteinase 2, anticorps matrix metalloproteinase-2, anticorps MMP2, anticorps Mmp2, anticorps mmp2, anticorps LOC657982, anticorps LOC100135793
    Sujet

    Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2

    Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

    ID gène
    4313
    UniProt
    P08253
    Pathways
    Activation of Innate immune Response
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