PAD4 anticorps

N° du produit ABIN7117295

Détail du produit anti-PAD4 anticorps

Antigène: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: peptidyl arginine deiminase, type IV

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:100-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PAD4

Antigène: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Autre désignation: PADI4 (PADI4 Produits)

Synonymes: anticorps PAD, anticorps PAD4, anticorps PADI5, anticorps PDI4, anticorps PDI5, anticorps Pad4, anticorps Pdi4, anticorps peptidyl arginine deiminase 4, anticorps peptidyl arginine deiminase, type IV, anticorps PADI4, anticorps Padi4

Sujet: Synonyms:PAD4, PADI5, PDI5 Background:Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54'(to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26'(to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3'(to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1(H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

Poids moléculaire: 74 kDa

ID gène: 23569

UniProt: Q9UM07