PIEZO1 anticorps

N° du produit ABIN7117527

Détail du produit anti-PIEZO1 anticorps

Antigène: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIEZO1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: family with sequence similarity 38, member A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PIEZO1

Antigène: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Autre désignation: Piezo1 (PIEZO1 Produits)

Synonymes: anticorps DHS, anticorps FAM38A, anticorps Mib, anticorps 9630020g22, anticorps Fam38a, anticorps mKIAA0233, anticorps piezo type mechanosensitive ion channel component 1, anticorps piezo-type mechanosensitive ion channel component 1, anticorps PIEZO1, anticorps Piezo1

Sujet: Synonyms:FAM38A, KIAA0233 Background:Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

Poids moléculaire: 250kd

ID gène: 9780

UniProt: Q92508