PIEZO1 anticorps (AA 2230-2420)

N° du produit ABIN7163444

Détail du produit anti-PIEZO1 anticorps

Antigène: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Épitope: AA 2230-2420

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIEZO1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIEZO1

Antigène: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Autre désignation: PIEZO1 (PIEZO1 Produits)

Synonymes: anticorps DHS, anticorps FAM38A, anticorps Mib, anticorps 9630020g22, anticorps Fam38a, anticorps mKIAA0233, anticorps piezo type mechanosensitive ion channel component 1, anticorps piezo-type mechanosensitive ion channel component 1, anticorps PIEZO1, anticorps Piezo1

Sujet:

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Aliases: DHS antibody, Fam38a antibody, Family with sequence similarity 38 member A antibody, KIAA0233 antibody, Membrane protein induced by beta-amyloid treatment antibody, Mib antibody, PIEZ1_HUMAN antibody, Piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Protein FAM38A antibody, Protein FAM38B antibody, Protein PIEZO1 antibody

UniProt: Q92508