Retinoblastoma Binding Protein 8 anticorps

N° du produit ABIN7118434

Cet anticorps Lapin Polyclonal détecte spécifiquement Retinoblastoma Binding Protein 8 dans ELISA et WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Retinoblastoma Binding Protein 8 anticorps (ABIN7118434)

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 8 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-Retinoblastoma Binding Protein 8 anticorps

Fonction: RBBP8 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: retinoblastoma binding protein 8

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Retinoblastoma Binding Protein 8

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Autre désignation: RBBP8

Sujet:

Synonyms: DNA endonuclease RBBP8|CtBP-interacting protein (CtIP)|Retinoblastoma-binding protein 8 (RBBP-8)|Retinoblastoma-interacting protein and myosin-like (RIM)|Sporulation in the absence of SPO11 protein 2 homolog (SAE2)|RBBP8|CTIP

Background: Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Poids moléculaire: 120 kDa

ID gène: 5932

UniProt: Q99708

Pathways: Cycle Cellulaire, Réparation de l'ADN