ZC3HAV1 anticorps

N° du produit ABIN7120939

Détail du produit anti-ZC3HAV1 anticorps

Antigène: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZC3HAV1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: zinc finger CCCH-type, antiviral 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:10000, IHC: 1:20-1:200, IP: 1:1000-1:4000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur ZC3HAV1

Antigène: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Autre désignation: ZC3HAV1 (ZC3HAV1 Produits)

Synonymes: anticorps 1200014N16Rik, anticorps 2900058M19Rik, anticorps 9130009D18Rik, anticorps 9830115L13Rik, anticorps ARTD13, anticorps D6Bwg1452e, anticorps ZAP, anticorps Zap, anticorps FLB6421, anticorps PARP13, anticorps ZC3H2, anticorps ZC3HDC2, anticorps zinc finger CCCH type, antiviral 1, anticorps zinc finger CCCH-type containing, antiviral 1, anticorps Zc3hav1, anticorps ZC3HAV1

Sujet: Synonyms:DKFZp686F2052, DKFZp686H1869, DKFZp686O19171, FLB6421, FLJ13288, ZAP, ZC3H2, ZC3HAV1, ZC3HDC2, Zinc finger antiviral protein Background:Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).

Poids moléculaire: 101 kDa

ID gène: 56829

UniProt: Q7Z2W4