ERAS belongs to the small GTPase superfamily. Ras family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. The ERas gene is expressed in embryonic stem (ES) cells and promotes their in vitro proliferation and tumorigenicity. ERas-null ES cells maintain pluripotency but show significantly reduced growth and tumorigenicity, which are rescued by expression of ERas complementary DNA or by activated phosphatidylinositol-3-OH kinase.
Synonyms: E ras, E-Ras, ecat5, Embryonic stem cell expressed Ras, Embryonic stem cell-expressed Ras, Eras, ES cell expressed Ras, GTPase ERas, Ha-Ras2, HRAS2, HRASP, MGC126691, MGC126693, OTTHUMP00000065857, RASE_HUMAN, Small GTPase protein E Ras, v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene, v Ha ras Harvey rat sarcoma viral oncogene homolog 2.