Recombinant ATM anticorps

N° du produit ABIN7127350

Détail du produit anti-ATM anticorps

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human ATM

Clone: 4E11

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IP:1:200-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM (ATM Produits)

Synonymes: anticorps ATM, anticorps Atm, anticorps CG6535, anticorps Dmel\\CG6535, anticorps Tefu, anticorps atm, anticorps atm/tefu, anticorps dATM, anticorps tef, anticorps Xatm, anticorps at1, anticorps atdc, anticorps tel1, anticorps telo1, anticorps AT1, anticorps ATA, anticorps ATC, anticorps ATD, anticorps ATDC, anticorps ATE, anticorps TEL1, anticorps TELO1, anticorps AI256621, anticorps C030026E19Rik, anticorps telomere fusion, anticorps ATM serine/threonine kinase L homeolog, anticorps ATM serine/threonine kinase, anticorps ataxia telangiectasia mutated, anticorps ataxia telangiectasia mutated (atm), anticorps serine/threonine-protein kinase ATM, anticorps tefu, anticorps atm.L, anticorps atm, anticorps ATM, anticorps EDI_100660, anticorps CpipJ_CPIJ001772, anticorps BDBG_08252, anticorps PAAG_02532, anticorps MCYG_05088, anticorps VDBG_06833, anticorps ACLA_015700, anticorps LOC5565620, anticorps MGYG_07634, anticorps PGTG_14279, anticorps Atm

Sujet:

Background: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

Aliases: Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ATM

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus