TNF alpha anticorps (C-Term)
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- Antigène Voir toutes TNF alpha Anticorps
- TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TNF alpha est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Affinity purification
- Immunogène
- C term -peptide of Human SFPQ
- Isotype
- IgG
- Top Product
- Discover our top product TNF alpha Anticorps primaire
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- Indications d'application
- WB:1:1000-1:2000, IHC:1:50-1:100,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Store at -20 °C or -80 °C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
- Autre désignation
- TNF (TNF alpha Produits)
- Synonymes
- anticorps DIF, anticorps TNF-alpha, anticorps TNFA, anticorps TNFSF2, anticorps RATTNF, anticorps Tnfa, anticorps tnf, anticorps TNF-a, anticorps TNFalpha, anticorps Tnfsf1a, anticorps TNFa, anticorps cTNF, anticorps Tnf-alpha, anticorps tnfa-like, anticorps TNF-ALPHA, anticorps dif, anticorps tnfa, anticorps xtnf, anticorps tnfsf2, anticorps tnf-alpha, anticorps Cachectin, anticorps tumor necrosis factor, anticorps tumor necrosis factor b (TNF superfamily, member 2), anticorps tumor necrosis factor alpha, anticorps tumor necrosis factor a (TNF superfamily, member 2), anticorps TNF, anticorps Tnf, anticorps tnf, anticorps tnfb, anticorps tnf-alpha, anticorps LOC103694380, anticorps tnfa
- Sujet
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Background: TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. Membrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer. Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages. Cellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell death. TNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosis. The role of TNF-α in autoimmunity is underscored by blocking TNF-α action to treat rheumatoid arthritis and Crohn's disease.
Aliases: APC1 antibody, APC1 protein antibody, Cachectin antibody, DIF antibody, Differentiation inducing factor antibody, Macrophage cytotoxic factor antibody, Tnf antibody, TNF superfamily member 2 antibody, TNF superfamily, member 2 antibody, TNF, macrophage derived antibody, TNF, monocyte derived antibody, TNF-a antibody, TNF-alpha antibody, TNFA antibody, TNFA_HUMAN antibody, TNFSF2 antibody, Tumor necrosis factor (TNF superfamily member 2) antibody, Tumor necrosis factor alpha antibody, Tumor necrosis factor antibody, Tumor necrosis factor ligand superfamily member 2 antibody, Tumor Necrosis Factor, Membrane Form antibody, Tumor necrosis factor, soluble form antibody
- UniProt
- P01375
- Pathways
- Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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