WEE1 anticorps (pSer642)
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- Antigène Voir toutes WEE1 Anticorps
- WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
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Épitope
- pSer642
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp WEE1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogène
- Peptide sequence around phosphorylation site of Serine 642(S-V-S(p)-L-T) derived from Human WEE1.
- Isotype
- IgG
- Top Product
- Discover our top product WEE1 Anticorps primaire
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- Indications d'application
- WB:1:500-1:1000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
- Autre désignation
- WEE1 (WEE1 Produits)
- Synonymes
- anticorps WEE1A, anticorps WEE1hu, anticorps ATWEE1, anticorps F22D16.3, anticorps F22D16_3, anticorps WEE1 kinase homolog, anticorps WEE1-KINASE, anticorps WEE1, anticorps Xe-Wee1B, anticorps XeWee1B, anticorps wee1-b, anticorps wee1a, anticorps wee2-a, anticorps xe-wee1a, anticorps xwee1, anticorps wee1, anticorps wee1b, anticorps wee1hu, anticorps xwee2, anticorps GB19689, anticorps Wee1A, anticorps fa20h03, anticorps wu:fa20h03, anticorps zgc:136514, anticorps WEE1 G2 checkpoint kinase, anticorps Wee1 kinase, anticorps WEE1-like kinase, anticorps WEE1 G2 checkpoint kinase S homeolog, anticorps wee1 homolog, anticorps WEE1 homolog 2, anticorps wee1-like protein kinase, anticorps WEE 1 homolog 1 (S. pombe), anticorps M phase inhibitor protein kinase Wee1, anticorps WEE1, anticorps Wee1, anticorps wee1.S, anticorps wee1-a, anticorps wee2, anticorps LOC551677, anticorps wee1
- Sujet
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Background:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Watanabe N., EMBO J. 14:1878-1891(1995).
Cichutek A., Cytogenet. Cell Genet. 93:277-283(2001).
Igarashi M., Nature 353:80-83(1991)Aliases: DKFZp686I18166 antibody, EC 2.7.10.2 antibody, FLJ16446 antibody, MGC105683 antibody, OTTHUMP00000231338 antibody, OTTHUMP00000231339 antibody, Wee 1 antibody, WEE 1 homolog 1 (S. pombe) antibody, WEE1 antibody, WEE1 homolog (S. pombe) antibody, Wee1 homolog antibody, WEE1 homolog S. pombe antibody, Wee1 like protein kinase antibody, Wee1 tyrosine kinase antibody, Wee1+ homolog antibody, Wee1+ S. pombe homolog antibody, WEE1, S. pombe, homolog of antibody, WEE1, somatic antibody, Wee1-like protein kinase antibody, WEE1_HUMAN antibody, WEE1A antibody, Wee1A kinase antibody, WEE1hu antibody
- UniProt
- P30291
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase
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