RPS6KA1 anticorps (pThr573)

N° du produit ABIN7138868

Cet anticorps Lapin Polyclonal détecte spécifiquement RPS6KA1 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour RPS6KA1 anticorps (pThr573) (ABIN7138868)

Antigène: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPS6KA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RPS6KA1 anticorps

Épitope: pThr573

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RPS6KA1

Antigène: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Autre désignation: RPS6KA1

Sujet:

Background:

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.

Eiichi Takahashi, J. Biol. Chem., Jul 1999, 274: 20206.
Ye Zhang, J. Biol. Chem., May 2002, 277: 19042 - 19048.
Ganesh R. Panta, Mol. Cell. Biol., Mar 2004, 24: 1823 - 1835.

Aliases: 90 kDa ribosomal protein S6 kinase 1 antibody, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 antibody, dJ590P13.1 antibody, EC 2.7.11.1 antibody, HU 1 antibody, HU1 antibody, KS6A1_HUMAN antibody, MAP kinase activated protein kinase 1a antibody, MAP kinase-activated protein kinase 1a antibody, MAPK-activated protein kinase 1a antibody, MAPKAP kinase 1a antibody, MAPKAPK-1a antibody, MAPKAPK1A antibody, MGC79981 antibody, Mitogen-activated protein kinase-activated protein kinase 1A antibody, OTTHUMP00000004113 antibody, p90 RSK1 antibody, p90-RSK 1 antibody, p90rsk antibody, p90RSK1 antibody, p90S6K antibody, pp90RSK1 antibody, Ribosomal protein S6 kinase 90kD 1 antibody, Ribosomal protein S6 kinase 90kD polypeptide 1 antibody, Ribosomal protein S6 kinase 90 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase alpha 1 antibody, Ribosomal protein S6 kinase alpha-1 antibody, Ribosomal protein S6 kinase polypeptide 1 antibody, Ribosomal S6 kinase 1 antibody, RPS6K1 alpha antibody, rps6ka antibody, Rps6ka1 antibody, RSK 1 antibody, RSK 1 p90 antibody, RSK antibody, RSK-1 antibody, RSK1 antibody, RSK1p90 antibody, S6K alpha 1 antibody, S6K-alpha-1 antibody

UniProt: Q15418

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades