ZAP70 anticorps (pTyr319)

N° du produit ABIN7138978

Cet anticorps anti-ZAP70 est un anticorps Lapin Polyclonal détectant ZAP70 dans WB, IHC, ELISA et IF. Adapté pour Humain.

Aperçu rapide pour ZAP70 anticorps (pTyr319) (ABIN7138978)

Antigène: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZAP70 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-ZAP70 anticorps

Épitope: pTyr319

Fonction: Phospho-ZAP70 (Tyr319) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 319 (S-P-Y(p)-S-D) derived from Human Zap-70.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ZAP70

Antigène: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Autre désignation: ZAP70

Sujet:

Background:

Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.

Salomon AR, et al. (2003) Proc Natl Acad Sci U S A, 100(2): 443-448
Ku GM, et al. (2001) EMBO J, 20(3): 457-465
Tang J, et al. (1999) Proc Natl Acad Sci U S A, 96(17): 9775-9780
Zhao Q, et al. (1996) Mol Cell Biol, 16(12): 6765-6774
Williams BL, et al. (1999) EMBO J, 18(7): 1832-1844
Adjali O, et al. (2005) J Clin Invest, 115(8): 2287-2295.

Aliases: 70 kDa zeta associated protein antibody, 70 kDa zeta-associated protein antibody, EC 2.7.10.2 antibody, FLJ17670 antibody, FLJ17679 antibody, Selective T cell defect antibody, SRK antibody, STD antibody, Syk related tyrosine kinase antibody, Syk-related tyrosine kinase antibody, Truncated ZAP kinase antibody, Tyrosine protein kinase ZAP70 antibody, Tyrosine-protein kinase ZAP-70 antibody, TZK antibody, ZAP 70 antibody, ZAP70 antibody, ZAP70_HUMAN antibody, Zeta chain associated protein kinase 70kD antibody, Zeta chain associated protein kinase 70 kDa antibody, Zeta chain associated protein kinase 70 kDa isoform 1 antibody, Zeta chain associated protein kinase 70 kDa isoform 2 antibody, Zeta chain of T cell receptor associated protein kinase 70 antibody, Zeta chain TCR associated protein kinase 70kD antibody, Zeta chain TCR associated protein kinase 70 kDa antibody

UniProt: P43403

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway