CENPA anticorps
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- Antigène Voir toutes CENPA Anticorps
- CENPA (Centromere Protein A (CENPA))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CENPA est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Peptide sequence around site of Ser (7) derived from Human Histone H3-like centromeric protein A
- Isotype
- IgG
- Top Product
- Discover our top product CENPA Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:10-1:100,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- CENPA (Centromere Protein A (CENPA))
- Autre désignation
- CENPA (CENPA Produits)
- Synonymes
- anticorps CENP-A, anticorps CenH3, anticorps Cenp-A, anticorps cenpx, anticorps cenp-a, anticorps sim2, anticorps Cenp-a, anticorps RGD1563607, anticorps CENPA, anticorps centromere protein A, anticorps centromere protein-A, anticorps centromeric histone-3 like protein, anticorps centromere-specific histone H3 CENP-A, anticorps cenp-A, anticorps centromere protein A L homeolog, anticorps histone H3-like centromeric protein A, anticorps CENPA, anticorps Cenpa, anticorps CENP-A, anticorps cenpa, anticorps cenp-A, anticorps cnp1, anticorps HAN_3g422, anticorps Cenp-a, anticorps cenpa.L, anticorps CMU_016480
- Sujet
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Background: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).
Aliases: CENP A antibody, CENP-A antibody, cenpa antibody, CENPA_HUMAN antibody, Centromere autoantigen A antibody, Centromere protein A 17 kDa antibody, Centromere protein A antibody, Histone H3 like centromeric protein A antibody, Histone H3-like centromeric protein A antibody
- UniProt
- P49450
- Pathways
- Chromatin Binding, Maintenance of Protein Location
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