PDK4 anticorps (AA 143-333)

N° du produit ABIN7142008

Cet anticorps anti-PDK4 est un anticorps Lapin Polyclonal détectant PDK4 dans IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour PDK4 anticorps (AA 143-333) (ABIN7142008)

Antigène: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDK4 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-PDK4 anticorps

Épitope: AA 143-333

Fonction: PDK4 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial protein (143-333AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PDK4

Antigène: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Autre désignation: PDK4

Sujet:

Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

Aliases: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 antibody, FLJ40832 antibody, mitochondrial antibody, Pdk4 antibody, PDK4_HUMAN antibody, Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial antibody, Pyruvate dehydrogenase kinase 4 antibody, Pyruvate dehydrogenase kinase isoenzyme 4 antibody, Pyruvate dehydrogenase kinase isoform 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 mitochondrial antibody

UniProt: Q16654

Pathways: Signalisation PI3K-Akt, Signalisation Hedgehog, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg