Casein Kinase 1 delta anticorps (Isoform delta) (HRP)

N° du produit ABIN7146861

Détail du produit anti-Casein Kinase 1 delta anticorps (HRP)

Antigène: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Épitope: AA 152-398, Isoform delta

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Casein Kinase 1 delta est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Casein kinase I isoform delta protein (152-398AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Casein Kinase 1 delta

Antigène: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Autre désignation: CSNK1D (CSNK1D Produits)

Synonymes: anticorps ASPS, anticorps CKIdelta, anticorps FASPS2, anticorps HCKID, anticorps 1200006A05Rik, anticorps AA409348, anticorps D930010H05Rik, anticorps CKI-delta, anticorps CKId, anticorps csnk1d, anticorps wu:fb69b03, anticorps wu:fj97a05, anticorps zgc:77627, anticorps CSNK1D, anticorps ckIdelta, anticorps Csnk1d, anticorps csnk1dl, anticorps wu:fb50c04, anticorps zgc:63971, anticorps casein kinase 1 delta, anticorps casein kinase 1, delta, anticorps casein kinase 1, delta b, anticorps casein kinase 1 delta S homeolog, anticorps casein kinase 1, delta a, anticorps CSNK1D, anticorps Csnk1d, anticorps csnk1d, anticorps csnk1db, anticorps Bm1_37175, anticorps csnk1d.S, anticorps csnk1da

Sujet:

Background: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Aliases: Casein Kinase 1 delta antibody, Casein kinase I delta isoform antibody, Casein kinase I isoform delta antibody, CKI delta antibody, CKI-delta antibody, CKId antibody, CKIdelta antibody, CSNK 1D antibody, CSNK1D antibody, HCKID antibody, KC1D_HUMAN antibody, Protein kinase CK1 delta antibody

UniProt: P48730

Pathways: Signalisation Hedgehog, M Phase