Aryl Hydrocarbon Receptor Nuclear Translocator Homolog (TGO) (AA 184-302) anticorps (HRP)
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- Antigène
- Aryl Hydrocarbon Receptor Nuclear Translocator Homolog (TGO)
- Épitope
- AA 184-302
- Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- HRP
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Class E basic helix-loop-helix protein 40 protein (184-302AA)
- Isotype
- IgG
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- Aryl Hydrocarbon Receptor Nuclear Translocator Homolog (TGO)
- Autre désignation
- BHLHE4
- Sujet
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Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
Aliases: BHE40_HUMAN antibody, bHLHB2 antibody, bHLHe40 antibody, Class B Basic Helix Loop Helix Protein 2 antibody, Class B basic helix-loop-helix protein 2 antibody, Class E basic helix loop helix protein 40 antibody, Class E basic helix-loop-helix protein 40 antibody, Clast5 antibody, DEC1 antibody, Differentially expressed in chondrocytes protein 1 antibody, E47 interaction protein 1 antibody, EIP1 antibody, Enhancer of split and hairy related protein 2 antibody, Enhancer-of-split and hairy-related protein 2 antibody, SHARP 2 antibody, SHARP-2 antibody, Stimulated by retinoic acid gene 13 protein antibody, STRA13 antibody
- UniProt
- O14503
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