POLR3E anticorps (AA 1-260) (Biotin)

N° du produit ABIN7150463

Détail du produit anti-POLR3E anticorps (Biotin)

Antigène: POLR3E (Polymerase (RNA) III (DNA Directed) Polypeptide E (80kD) (POLR3E))

Épitope: AA 1-260

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3E est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human DNA-directed RNA polymerase III subunit RPC5 protein (1-260AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur POLR3E

Antigène: POLR3E (Polymerase (RNA) III (DNA Directed) Polypeptide E (80kD) (POLR3E))

Autre désignation: POLR3E (POLR3E Produits)

Synonymes: anticorps RPC5, anticorps SIN, anticorps Sin, anticorps MGC78924, anticorps RGD1308086, anticorps wu:fb12d10, anticorps wu:fs42e03, anticorps zgc:55592, anticorps RNA polymerase III subunit E, anticorps polymerase (RNA) III (DNA directed) polypeptide E, anticorps polymerase (RNA) III (DNA directed) polypeptide E (80kD) L homeolog, anticorps polymerase (RNA) III (DNA directed) polypeptide E (80kD), anticorps DNA-directed RNA polymerase III subunit RPC5, anticorps POLR3E, anticorps Polr3e, anticorps polr3e.L, anticorps polr3e, anticorps LOC608689

Sujet:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Aliases: POLR3E antibody, KIAA1452 antibody, DNA-directed RNA polymerase III subunit RPC5 antibody, RNA polymerase III subunit C5 antibody, DNA-directed RNA polymerase III 80 kDa polypeptide antibody

UniProt: Q9NVU0