MLL5/KMT2E anticorps (AA 182-316) (Biotin)

N° du produit ABIN7155467

Détail du produit anti-MLL5/KMT2E anticorps (Biotin)

Antigène: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Épitope: AA 182-316

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLL5/KMT2E est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MLL5/KMT2E

Antigène: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Autre désignation: KMT2E (MLL5 Produits)

Synonymes: anticorps HDCMC04P, anticorps MLL5, anticorps 1810033J14Rik, anticorps 9530077A04Rik, anticorps D230038D11Rik, anticorps Mll5, anticorps lysine methyltransferase 2E, anticorps lysine (K)-specific methyltransferase 2E, anticorps KMT2E, anticorps Kmt2e

Sujet:

Background: Histone methyltransferase that specifically mono- and dimethylates \'Lys-4\' of histone H3 (H3K4me1 and H3K4me2). H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

Aliases: HDCMC04P antibody, Histone lysine N methyltransferase MLL5 antibody, Histone-lysine N-methyltransferase MLL5 antibody, KMT2E antibody, Lysine N methyltransferase 2E antibody, Lysine N-methyltransferase 2E antibody, MGC70452 antibody, Mll5 antibody, MLL5_HUMAN antibody, Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog, Drosophila) antibody, Myeloid/lymphoid or mixed lineage leukemia 5 antibody, Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody, Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody

UniProt: Q8IZD2

Pathways: Retinoic Acid Receptor Signaling Pathway, L'effet Warburg