ERK2 anticorps (AA 310-360)

N° du produit ABIN7159972

Détail du produit anti-ERK2 anticorps

Antigène: ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))

Épitope: AA 310-360

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Mitogen-activated protein kinase 1 protein (310-360AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ERK2

Antigène: ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))

Autre désignation: MAPK1 (MAPK1 Produits)

Synonymes: anticorps ERK-1, anticorps ERK1, anticorps ERT2, anticorps HS44KDAP, anticorps HUMKER1A, anticorps P44ERK1, anticorps P44MAPK, anticorps PRKM3, anticorps p44-ERK1, anticorps p44-MAPK, anticorps Erk-1, anticorps Erk1, anticorps Ert2, anticorps Esrk1, anticorps Mnk1, anticorps Mtap2k, anticorps Prkm3, anticorps p44, anticorps p44erk1, anticorps p44mapk, anticorps ERK, anticorps ERK2, anticorps ERT1, anticorps MAPK2, anticorps P42MAPK, anticorps PRKM1, anticorps PRKM2, anticorps p38, anticorps p40, anticorps p41, anticorps p41mapk, anticorps 9030612K14Rik, anticorps AA407128, anticorps AU018647, anticorps C78273, anticorps Erk2, anticorps Prkm1, anticorps p42mapk, anticorps zERK2, anticorps MAPK1, anticorps Xp42, anticorps erk, anticorps erk2, anticorps ert1, anticorps mapk, anticorps mapk1b, anticorps mapk2, anticorps mpk1, anticorps prkm1, anticorps prkm2, anticorps mapk1, anticorps mapk1a, anticorps xp42, anticorps ATMPK1, anticorps F14N23.9, anticorps F14N23_9, anticorps MITOGEN-ACTIVATED PROTEIN KINASE, anticorps mitogen-activated protein kinase 1, anticorps MNK1, anticorps ATMPK2, anticorps MITOGEN-ACTIVATED PROTEIN KINASE HOMOLOG 2, anticorps T30E16.13, anticorps T30E16_13, anticorps mitogen-activated protein kinase homolog 2, anticorps mitogen-activated protein kinase 3, anticorps mitogen-activated protein kinase 1, anticorps mitogen activated protein kinase 1, anticorps mitogen-activated protein kinase 1 L homeolog, anticorps mitogen-activated protein kinase 1 S homeolog, anticorps mitogen activated protein kinase 3, anticorps mitogen-activated protein kinase homolog 2, anticorps MAPK3, anticorps Mapk3, anticorps MAPK1, anticorps Mapk1, anticorps mapk1, anticorps mapk1.L, anticorps mapk1.S, anticorps PfMAP1, anticorps MPK1, anticorps PVX_084965, anticorps LOC9328617, anticorps Tsp_01601, anticorps MPK2

Sujet:

Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.

Aliases: ERK 2 antibody, ERK-2 antibody, ERT1 antibody, Extracellular Signal Regulated Kinase 2 antibody, Extracellular signal-regulated kinase 2 antibody, MAP kinase 1 antibody, MAP kinase 2 antibody, MAP kinase isoform p42 antibody, MAPK 1 antibody, MAPK 2 antibody, Mapk1 antibody, MAPK2 antibody, Mitogen-activated protein kinase 1 antibody, Mitogen-activated protein kinase 2 antibody, MK01_HUMAN antibody, P38 antibody, P40 antibody, P41 antibody, p42-MAPK antibody, P42MAPK antibody, PRKM1 antibody, PRKM2 antibody, protein kinase, mitogen-activated, 1 antibody, protein kinase, mitogen-activated, 2 antibody, protein tyrosine kinase ERK2 antibody

UniProt: P28482

Pathways: Signalisation MAPK, Signalisation RTK, Apoptose, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagy, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, S100 Proteins