ZFP36 anticorps (AA 16-103) (FITC)
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- Antigène Voir toutes ZFP36 Anticorps
- ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))
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Épitope
- AA 16-103
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ZFP36 est conjugé à/à la FITC
- Application
- Veuillez nous consulter SVP
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human mRNA decay activator protein ZFP36 protein (16-103AA)
- Isotype
- IgG
- Top Product
- Discover our top product ZFP36 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))
- Autre désignation
- ZFP36 (ZFP36 Produits)
- Synonymes
- anticorps G0S24, anticorps GOS24, anticorps NUP475, anticorps RNF162A, anticorps TIS11, anticorps TTP, anticorps zfp-36, anticorps c3h-1, anticorps g0s24, anticorps gos24, anticorps nup475, anticorps rnf162a, anticorps tis11, anticorps ttp, anticorps ZFP36, anticorps C3H-1, anticorps Gos24, anticorps Nup475, anticorps TIS11D, anticorps TISII, anticorps Tis11, anticorps Ttp, anticorps Zfp-36, anticorps ZFP36 ring finger protein, anticorps ZFP36 ring finger protein L homeolog, anticorps tristetraproline, anticorps Tristetraproline, anticorps similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth, anticorps zinc finger protein 36, anticorps ZFP36, anticorps zfp36.L, anticorps EDI_287240, anticorps Bm1_42085, anticorps LOAG_03119, anticorps zfp36, anticorps Zfp36
- Sujet
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Background: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583). Acts as an 3\'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3\'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses, suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism, assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping, enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077).
Aliases: G0/G1 switch regulatory protein 24 antibody, G0S24 antibody, GOS24 antibody, Growth factor-inducible nuclear protein NUP475 antibody, NUP475 antibody, Protein TIS11A antibody, RNF162A antibody, TIS 11 antibody, TIS11 antibody, TIS11A antibody, Tristetraprolin antibody, Tristetraproline antibody, TTP antibody, TTP_HUMAN antibody, Zfp-36 antibody, ZFP36 antibody, Zinc finger protein 36 antibody, Zinc finger protein 36 homolog antibody, Zinc finger protein 36, C3H type, homolog (mouse) antibody, Zinc finger protein, C3H type, 36 homolog antibody
- UniProt
- P26651
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