NAE1 anticorps (Regulatory Subunit)

N° du produit ABIN7161137

Détail du produit anti-NAE1 anticorps

Antigène: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Épitope: AA 1-220, Regulatory Subunit

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAE1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human NEDD8-activating enzyme E1 regulatory subunit protein (1-220AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NAE1

Antigène: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Autre désignation: NAE1 (NAE1 Produits)

Synonymes: anticorps APPBP1, anticorps CG7828, anticorps Dmel\\CG7828, anticorps anon-WO0140519.225, anticorps dAPP-BP1, anticorps dAPPBP1, anticorps A-116A10.1, anticorps ula-1, anticorps Appbp1, anticorps 59kDa, anticorps appbp1, anticorps zgc:66148, anticorps beta-Amyloid precursor protein binding protein 1, anticorps NEDD8 activating enzyme E1 subunit 1, anticorps NEDD8 activating enzyme E1 subunit 1 S homeolog, anticorps nedd8 activating enzyme E1 subunit 1, anticorps NEDD8-activating enzyme E1 regulatory subunit, anticorps APP-BP1, anticorps NAE1, anticorps Nae1, anticorps nae1.S, anticorps nae1, anticorps ula-1

Sujet:

Background: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Aliases: 59 kDa antibody, A 116A10.1 antibody, Amyloid beta precursor protein binding protein 1 59kD antibody, Amyloid beta precursor protein binding protein 1 59 kDa antibody, Amyloid beta precursor protein binding protein 1 antibody, Amyloid beta precursor protein binding protein 1, 59 kDa antibody, Amyloid beta precursor protein-binding protein 1 antibody, Amyloid protein binding protein 1 antibody, Amyloid protein-binding protein 1 antibody, APP BP1 antibody, APP-BP1 antibody, APPBP 1 antibody, APPBP1 antibody, HPP 1 antibody, HPP1 antibody, NAE 1 antibody, NAE1 antibody, NEDD8 activating enzyme E1 regulatory subunit antibody, NEDD8 activating enzyme E1 subunit 1 antibody, NEDD8 activating enzyme E1 subunit antibody, NEDD8-activating enzyme E1 regulatory subunit antibody, Proto oncogene protein 1 antibody, Proto-oncogene protein 1 antibody, Protooncogene protein 1 antibody, ula 1 antibody, ULA1_HUMAN antibody

UniProt: Q13564