NUDT15 anticorps (AA 1-164)

N° du produit ABIN7162069

Détail du produit anti-NUDT15 anticorps

Antigène: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Épitope: AA 1-164

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUDT15 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 protein (1-164AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NUDT15

Antigène: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Autre désignation: NUDT15 (NUDT15 Produits)

Synonymes: anticorps MTH2, anticorps RP11-90M2.1, anticorps 6530403O17, anticorps A730068G11Rik, anticorps nudix hydrolase 15, anticorps nudix (nucleoside diphosphate linked moiety X)-type motif 15, anticorps NUDT15, anticorps Nudt15

Sujet:

Background: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).

Aliases: 8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody, 8-oxo-dGTPase NUDT15 antibody, A730068G11Rik antibody, EC 3.1.6.- antibody, FLJ10956 antibody, MGC104352 antibody, MTH2 antibody, MutT homolog 2 antibody, Nucleoside diphosphate-linked moiety X motif 15 antibody, NUD15_HUMAN antibody, Nudix (nucleoside diphosphate linked moiety X)-type motif antibody, Nudix motif 15 antibody, NUDT15 antibody, OTTHUMP00000018389 antibody, Probable 7 antibody, Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody, RP11-90M2.1 antibody

UniProt: Q9NV35