PIP5K1A anticorps (AA 293-562)

N° du produit ABIN7163185

Détail du produit anti-PIP5K1A anticorps

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Épitope: AA 293-562

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIP5K1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha protein (293-562AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIP5K1A

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Autre désignation: PIP5K1A (PIP5K1A Produits)

Synonymes: anticorps Pip5k1b, anticorps pip5k1c, anticorps PIP5K1A, anticorps pip5k1b, anticorps Pipk5a, anticorps Pipk5b, anticorps pip5k1a, anticorps zgc:110576, anticorps im:7140933, anticorps zgc:158838, anticorps phosphatidylinositol-4-phosphate 5-kinase type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b, anticorps PIP5K1A, anticorps Pip5k1a, anticorps pip5k1a.L, anticorps pip5k1a, anticorps pip5k1aa, anticorps pip5k1ab

Sujet:

Background: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

Aliases: 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha antibody, Phosphatidylinositol 4 phosphate 5 kinase type I alpha antibody, Phosphatidylinositol-4-phosphate 5-kinase type I alpha antibody, Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha antibody, PI4P5K Ia antibody, PI51A_HUMAN antibody, PIP5K A antibody, PIP5K1-alpha antibody, Pip5k1a antibody, PIP5KIalpha antibody, PtdIns(4)P-5-kinase 1 alpha antibody

UniProt: Q99755

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA