SOCS1 anticorps (AA 1-211)

N° du produit ABIN7170991

Cet anticorps anti-SOCS1 est un anticorps Lapin Polyclonal détectant SOCS1 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour SOCS1 anticorps (AA 1-211) (ABIN7170991)

Antigène: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SOCS1 anticorps

Épitope: AA 1-211

Fonction: SOCS1 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SOCS1

Antigène: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Autre désignation: SOCS1

Sujet:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Aliases: CISH 1 antibody, CISH1 antibody, Cytokine inducible SH2 protein 1 antibody, JAB antibody, JAK binding protein antibody, JAK-binding protein antibody, Janus kinase binding protein antibody, SOCS 1 antibody, SOCS-1 antibody, Socs1 antibody, SOCS1_HUMAN antibody, SSI 1 antibody, SSI-1 antibody, SSI1 antibody, STAT induced STAT inhibitor 1 antibody, STAT-induced STAT inhibitor 1 antibody, Suppressor of cytokine signaling 1 antibody, Supressor of cytokine signalling 1 antibody, TEC interacting protein 3 antibody, Tec-interacting protein 3 antibody, TIP 3 antibody, TIP-3 antibody, TIP3 antibody

UniProt: O15524

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Signalisation TLR, Response to Growth Hormone Stimulus