CD3 epsilon anticorps (AA 23-207)

N° du produit ABIN7171386

L’anticorps Lapin Polyclonal anti-CD3 epsilon a été validé pour WB, IHC, IF et ELISA. Il convient pour détecter CD3 epsilon dans des échantillons de Humain.

Aperçu rapide pour CD3 epsilon anticorps (AA 23-207) (ABIN7171386)

Antigène: CD3 epsilon (CD3E)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD3 epsilon est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Détail du produit anti-CD3 epsilon anticorps

Épitope: AA 23-207

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human T-cell surface glycoprotein CD3 epsilon chain protein (23-207AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CD3 epsilon

Antigène: CD3 epsilon (CD3E)

Autre désignation: CD3E

Sujet:

Background: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

Aliases: CD3 epsilon antibody, CD3e antibody, CD3e antigen antibody, CD3e antigen epsilon polypeptide (TiT3 complex) antibody, CD3E antigen epsilon polypeptide antibody, CD3E antigen, epsilon subunit antibody, CD3e molecule epsilon antibody, CD3e molecule, epsilon (CD3 TCR complex) antibody, CD3e molecule, epsilon (CD3-TCR complex) antibody, CD3E_HUMAN antibody, IMD18 antibody, T cell antigen receptor complex epsilon subunit of T3 antibody, T cell surface antigen T3/Leu 4 epsilon chain antibody, T cell surface glycoprotein CD3 epsilon chain antibody, T-cell surface antigen T3/Leu-4 epsilon chain antibody, T-cell surface glycoprotein CD3 epsilon chain antibody, T3E antibody, TCRE antibody

UniProt: P07766

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway