RAP1 anticorps (AA 1-280)
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- Antigène Voir toutes RAP1 (TERF2IP) Anticorps
- RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))
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Épitope
- AA 1-280
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RAP1 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)
- Isotype
- IgG
- Top Product
- Discover our top product TERF2IP Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))
- Autre désignation
- TERF2IP (TERF2IP Produits)
- Synonymes
- anticorps DRIP5, anticorps RAP1, anticorps Rap1, anticorps cRAP1, anticorps TERF2 interacting protein, anticorps telomeric repeat binding factor 2, interacting protein, anticorps TERF2IP, anticorps Terf2ip
- Sujet
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Background: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5\\\'-TTAGGG-3\\\' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Aliases: Dopamine receptor interacting protein 5 antibody, Dopamine receptor-interacting protein 5 antibody, DRIP 5 antibody, DRIP5 antibody, hRap1 antibody, MGC105533 antibody, RAP 1 antibody, RAP1 homolog antibody, RAP1, yeast, homolog if antibody, RAP1, yeast, homolog of antibody, Repressor/activator protein 1 homolog antibody, TE2IP_HUMAN antibody, Telomeric Repeat Binding Factor 2 Interacting Protein antibody, Telomeric repeat-binding factor 2-interacting protein 1 antibody, TERF2-interacting protein antibody, TERF2-interacting telomeric protein 1 antibody, TERF2IP antibody, TRF2 Interacting Telomeric Protein RAP1 antibody, TRF2 interacting telomeric RAP1 protein antibody, TRF2-interacting telomeric protein 1 antibody, TRF2-interacting telomeric protein antibody
- UniProt
- Q9NYB0
- Pathways
- Cycle Cellulaire, Telomere Maintenance
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