TOR1A anticorps (AA 88-125) (Biotin)

N° du produit ABIN7172306

Détail du produit anti-TOR1A anticorps (Biotin)

Antigène: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Épitope: AA 88-125

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOR1A est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Torsin-1A protein (88-125AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TOR1A

Antigène: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Autre désignation: TOR1A (TOR1A Produits)

Synonymes: anticorps Dyt1, anticorps DQ2, anticorps DYT1, anticorps torsinA, anticorps torsin family 1, member A, anticorps torsin family 1 member A, anticorps torsin family 1, member A (torsin A), anticorps Tor1a, anticorps TOR1A

Sujet:

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Aliases: DQ2 antibody, Dystonia 1 antibody, Dystonia 1 protein antibody, Dystonia 1 torsion antibody, Dyt1 antibody, TOR1A antibody, TOR1A_HUMAN antibody, Torsin 1A antibody, Torsin A antibody, Torsin family 1 member A antibody, Torsin family 1, member A (torsin A) antibody, Torsin-1A antibody

UniProt: O14656

Pathways: SARS-CoV-2 Protein Interactome