XRCC6 anticorps (AA 2-609)

N° du produit ABIN7175905

Détail du produit anti-XRCC6 anticorps

Antigène: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Épitope: AA 2-609

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XRCC6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human X-ray repair cross-complementing protein 6 ptotein (2-609AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur XRCC6

Antigène: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Autre désignation: XRCC6 (XRCC6 Produits)

Synonymes: anticorps CTC75, anticorps CTCBF, anticorps G22P1, anticorps KU70, anticorps ML8, anticorps TLAA, anticorps 70kDa, anticorps G22p1, anticorps Ku70, anticorps Kup70, anticorps X-ray repair cross complementing 6, anticorps ATP-dependent DNA helicase II, 70 kDa subunit, anticorps X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog, anticorps X-ray repair complementing defective repair in Chinese hamster cells 6, anticorps XRCC6, anticorps Bm1_41430, anticorps xrcc6.L, anticorps Xrcc6

Sujet:

Background: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3\\\'-5\\\' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5\\\'-deoxyribose-5-phosphate lyase (5\\\'-dRP lyase), by catalyzing the beta-elimination of the 5\\\' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5\\\'-dRP lyase activity allows to \\\'clean\\\' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

Aliases: 5''-deoxyribose-5-phosphate lyase Ku70 antibody, 5''-dRP lyase Ku70 antibody, 70 kDa subunit of Ku antigen antibody, ATP dependent DNA helicase 2 subunit 1 antibody, ATP dependent DNA helicase II 70 kDa subunit antibody, ATP-dependent DNA helicase 2 subunit 1 antibody, ATP-dependent DNA helicase II 70 kDa subunit antibody, CTC box binding factor 75 kDa subunit antibody, CTC box-binding factor 75 kDa subunit antibody, CTC75 antibody, CTCBF antibody, DNA repair protein XRCC6 antibody, G22P1 antibody, Ku 70 antibody, Ku autoantigen p70 subunit antibody, Ku autoantigen, 70 kDa antibody, Ku p70 antibody, Ku70 antibody, Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody, Kup70 antibody, Lupus Ku autoantigen protein p70 antibody, ML8 antibody, Thyroid autoantigen 70kD (Ku antigen) antibody, Thyroid autoantigen antibody, Thyroid lupus autoantigen antibody, Thyroid lupus autoantigen p70 antibody, Thyroid-lupus autoantigen antibody, TLAA antibody, X ray repair complementing defective repair in Chinese hamster cells 6 antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody, X-ray repair cross-complementing protein 6 antibody, XRCC 6 antibody, Xrcc6 antibody, XRCC6_HUMAN antibody

UniProt: P12956

Pathways: Réparation de l'ADN